ATR inhibitor 2 是一种 ATP 竞争性的，具有口服活性的，选择性的 ATR 抑制剂，Ki<150 pm。atr inhibitor 2 抑制 atr 驱动的磷酸化检查点激酶-1 (chk1) 磷酸化, ic50值为 8 nm。具有抗肿瘤活性。
货号:ajcx17024
CAS:1613191-99-3
分子式:C25H29F2N9O3
分子量：541.55
溶解度:DMSO: 25 mg/mL (46.16 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ATR inhibitor 2 is an ATP-competitive, orally active, selective ATR inhibitor, with a Ki of<150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].

[1]. Frank T. Zenke, et al. Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy. Experimental and Molecular Therapeutics. [2]. Gorecki L, et al. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy. Pharmacol Ther. 2020 Feb 26:107518.