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Afizagabar
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Afizagabar图片
规格:98%
分子量:365.38
包装与价格:
包装价格(元)
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Afizagabar (S44819) 是一种首创的,有竞争性的,选择性的 α5-GABAAR 拮抗剂,对α5β2γ2 的IC50 值 585 nM,对 α5β3γ2 的 Ki 为 66 nM。Afizagabar 增强海马突触可塑性并显示促认知功效。
货号:ajcx34492
CAS:1398496-82-6
分子式:C19H12FN3O2S
分子量:365.38
溶解度:DMSO : 6.25 mg/mL (17.11 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1].

Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons[1].

Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine[1].

[1]. Etherington LA, et al. Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent. Neuropharmacology. 2017;125:353-364.

 
 
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