λ-Cyhalothrin 是一种高效的广谱的 II 型合成除虫菊酯杀虫剂，含有 α-氰基。λ-Cyhalothrin 在各种应用中用于防治多种害虫 (pests)。λ-Cyhalothrin 是一种神经毒素，靶向中枢神经系统中神经元膜的钠通道 (sodium channels)。
货号:ajcx33020
CAS:91465-08-6
分子式:C23H19ClF3NO3
分子量：449.85
溶解度:DMSO : 33.33 mg/mL (74.09 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

λ-Cyhalothrin is a high efficiency, broad-spectrum type II synthetic pyrethroid insecticide containing α-cyano group. λ-Cyhalothrin is used to control a wide range of pests in a variety of applications. λ-Cyhalothrin is a neurotoxin that targets sodium channels in the membranes of neurons in the central nervous system[1].

The mechanism of λ-Cyhalothrin toxicity produces delay in sodium channel inactivation, which leads to persistent depolarization of the nerve membrane. λ-Cyhalothrin produces membrane depolarization, calcium ion infl ux, and neurotransmitter release from rat brain synaptosomes[1]. λ-Cyhalothrin possesses estrogenic properties and has an ability to function as a xenoestrogen promoting human breast carcinoma cell proliferation in vitro[1].λ-Cyhalothrin has found multiple uses in pest (fleas, cockroaches, flies, and ants) control[1].λ-Cyhalothrin is highly effective against the malaria transmitting species of Anopheles[1].

The effect of λ-Cyhalothrin (i.p.) on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA) is investigated. Neither memory nor movement co-ordination are impaired by BCCA or λ-Cyhalothrin. Exploratory locomotor activity is significantly reduced in the BCCA/LCH group. Spontaneous movement activity is significantly reduced in the BCCA/λ-Cyhalothrin group . Exposure to λ-Cyhalothrin coexisting with BCCA decreases motor activity in the mice in 2 subsequent 30-min[1].

[1]. Barbara Nieradko-Iwanicka, et al. Effect of Lambda-Cyhalothrin on Memory and Movement in Mice After Transient Incomplete Cerebral Ischemia. Ann Agric Environ Med. 2011;18(1):41-5.