2′-Deoxy-2′-fluoroguanosine，一种核苷类似物，是有效的流感病毒 (influenza virus) 抑制剂，抑制 A 型和 B 型流感病毒的 EC90 值<0.35 µM。2′-Deoxy-2′-fluoroguanosine 可显着抑制流感病毒在上呼吸道中的复制，从而改善发烧和鼻腔炎症。
货号:ajcx32730
CAS:78842-13-4
分子式:C10H12FN5O4
分子量：285.23
溶解度:DMSO : 50 mg/mL (175.30 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2′-Deoxy-2′-fluoroguanosine, a nucleoside analog, is a potent inhibitor of influenza virus strains, with an EC90 of<0.35 µM for influenza virus A and B strains. 2′-Deoxy-2′-fluoroguanosine significantly inhibits replication of influenza virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation[1][2].

参考文献:
[1]. Tisdale M, et, al. Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine. Antimicrob Agents Chemother. 1995 Nov;39(11):2454-8.
[2]. Jakeman KJ, et, al. Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets. Antimicrob Agents Chemother. 1994 Aug;38(8):1864-7.