ERAP1-in-1是内质网氨基肽酶1(ERAP1)抑制剂，能竞争性地抑制ERAP1对代表性生物底物九聚物肽的作用。
货号:ajcx30594
CAS:865273-97-8
分子式:C20H21F3N2O5S
分子量：458.45
溶解度:DMSO: 250 mg/mL (545.32 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates[1].

ERAP1-IN-1 allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substratesv[1].ERAP1-IN-1 (50 µM) exhibits specific inhibition of ERAP1 in the cellular context[1].

[1]. Maben Z, et al. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem. 2019 Dec 30.