SAHM1 是一种类似于主脑样 (MAML) 的显性阴性形式的肽模拟物，可抑制典型的 Notch 转录复合物形成。
货号:ajcx27622
CAS:2050906-89-1
分子式:C94H162N36O23S
分子量：2196.58
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Ashley et al (2015) Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 116 2598 PMID:25914241 |Bagheri et al (2018) Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 12 304 PMID:28482141 |KleinJan et al (2018) The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 142 76 PMID:29111218