NHI 2 是一种有效的 LDH-A 抑制剂。 NHI 2 是一种有效的抗糖酵解剂。 NHI 2具有研究癌症疾病的潜力。
货号:ajcx27020
CAS:1269802-97-2
分子式:C17H12F3NO3
分子量：335.28
溶解度:DMSO: 25 mg/ml,Ethanol: 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine on LPC006 and PANC-1 cells. Also inhibits ferroptosis.

Maftouh et al (2014) Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia. Br.J.Cancer 110 172 PMID:24178759 |Calvaresi et al (2013) Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem 14 2263 PMID:24174263 |Granchi et al (2013) Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org.Biomol.Chem. 11 6588 PMID:23986182 |Jacobsen et al (2018) APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells. Cell Chem.Biol. 25 1337 PMID:30122371