JKE-1716 是一种有效的、选择性的含硝酸 GPX4 抑制剂。
货号:ajcx22698
CAS:2421118-05-8
分子式:C20H20Cl2N4O4
分子量：451.3
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：
现货Background:
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
