Aminohexylgeldanamycin(AHGDM)，Geldanamycin的衍生物，是一种热休克蛋白90(HSP90)抑制剂。Aminohexylgeldanamycin具有抗血管生成和抗肿瘤活性。
货号:ajcx32014
CAS:485395-71-9
分子式:C34H52N4O8
分子量：644.8
溶解度:DMSO: 200 mg/mL (310.17 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1].

HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].

[1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270. [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.