High affinity and selective CA IX and CA XII inhibitor
货号:ajcx27128
CAS:1330061-67-0
分子式:C15H17N3O4S
分子量：335.38
溶解度:DMSO: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID:22621623