High affinity NK1 antagonist
货号:ajcx26810
CAS:145877-52-7
分子式:C20H23F3N2O2.2HCl
分子量：453.33
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

High affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.

McLean et al (1996) Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J.Pharmacol.Exp.Ther. 277 900 PMID:8627572 |Gonsalves et al (1996) Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets. Eur.J.Pharmacol. 305 181 PMID:8813551 |Auais et al (2003) Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. Am.J.Physiol. Lung Cell Mol.Physiol. 285 L105 PMID:12639840