A TLR4 antagonist
货号:ajcx25072
CAS:956507-49-6
分子式:C25H32ClN3O3
分子量：458
溶解度:Methyl Acetate: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

T-5342126 is a toll-like receptor 4 (TLR4) antagonist.¹It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀= 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.²

1.Chavez, S.A., Martinko, A.J., Lau, C., et al.Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antisepticsJ. Med. Chem.54(13)4659-4669(2011) 2.Bajo, M., Montgomery, S.E., Cates, L.N., et al.Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent miceAlcohol Alcohol.51(5)541-548(2016)