AWL-II-38.3 是一种有效的 ephrin-A 受体 (EphA3) 激酶抑制剂，对 Src 家族激酶和 b-raf 均没有显着的细胞活性。
货号:ajcx35412
CAS:1135205-94-5
分子式:C23H18F3N5O3
分子量：469.42
溶解度:DMSO : 66.67 mg/mL (142.03 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].

AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].

[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
[2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.