C53H74BrN9O9S
货号:ajcx28162
CAS:2052306-13-3
分子式:C53H74BrN9O9S
分子量：1093.19
溶解度:DMSO|109.32|100|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent TANK-binding kinase 1 (TBK1) Degrader (DC50 = 12 nM, Dmax = 96%). Exhibits >50-fold selectivity for TBK1 over the closely related IKKε. Comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. Brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation. Negative control TBK1 control PROTAC? 4? also available.