An active metabolite of mephenytoin
货号:ajcx25952
CAS:631-07-2
分子式:C11H12N2O2
分子量：204.2
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：
现货Background:
Nirvanol is an active metabolite of mephenytoin, a substrate of the cytochrome P450 (CYP) isoform CYP2C19 with anticonvulsant activities.1It blocks the hind leg tonic extensor phase in a mouse model of seizures induced by maximal electroshock (MES; ED50= 30 mg/kg).
1.Kupferberg, H.J., and Yonekawa, W.The metabolism of 3-methyl-5-ethyl-5-phenylhydantoin (mephenytoin) to 5-ethyl-5-phenylhydantoin (nirvanol) in mice in relation to anticonvulsant activityDrug Metab. Dispos.3(1)26-29(1975)
