An internal standard for the quantification of alizapride
货号:ajcx25118
CAS:N/A
分子式:C15[13C]H18D3N5O2·HCl
分子量：355.9
溶解度:DMSO: soluble,Methanol: soluble,Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Alizapride-¹³C-d₃is intended for use as an internal standard for the quantification of alizapride by GC- or LC-MS. Alizapride is a dopamine D₂receptor antagonist (K_i= 66-340 nM in radioligand binding assays).¹It is selective for dopamine D₂over α₁-, α₂-, and β-adrenergic receptors (IC₅₀s = >10 µM for all). It reduces decreases in gastrointestinal transit induced by dopamine , apomorphine, or bromocriptine in rats when administered at a dose of 5 mg/kg.²Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.

1.Chivers, J.K., Gommeren, W., Leysen, J.E., et al.Comparison of the in-vitro receptor selectivity of substituted benzamide drugs for brain neurotransmitter receptorsJ. Pharm. Pharmacol.40(6)415-421(1988) 2.Dhasmana, K.M., VillalÓn, C.M., Zhu, Y.N., et al.The role of dopamine (D2), α and β-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the ratPharmacol. Res.27(4)335-347(1993)