An inhibitor of the RAD51-BRCA2 interaction
货号:ajcx22032
CAS:391889-85-3
分子式:C28H24ClN3O3
分子量：486
溶解度:DMF: 11mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 10mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC₅₀= 19 µM in a cell-free competitive ELISA).¹It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 µM. CAY10760 (20 µM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib .

1.Bagnolini, G., Milano, D., Manerba, M., et al.Synthetic lethality in pancreatic cancer: Discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparibJ. Med. Chem.63(5)2588-2619(2020)