A neuropeptide with diverse biological activities
货号:ajcx21748
CAS:N/A
分子式:C17H18D5NO3
分子量：294.4
溶解度:Chloroform: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Atropine-d₅is intended for use as an internal standard for the quantification of atropine by GC- or LC-MS. Atropine is a tropane alkaloid that has been found inA. belladonnaand acts as a non-selective, competitive antagonist of muscarinic acetylcholine receptors (K_Bs = 0.16-1.26 nM for the M₁-M₅receptors).^1,2Atropine increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine receptor sites, and decreases bronchial secretions.³Formulations containing atropine have been used to induce mydriasis for ophthalmological exams and in the treatment of cardiac arrest and organophosphate pesticide or muscarinic mushroom poisoning.

1.Sharp, J.M., and Doran, P.M.Characteristics of growth and tropane alkaloid synthesis in Atropa belladonna roots transformed by Agrobacterium rhizogenesJ. Biotechnol.16(3-4)171-185(1990) 2.Caulfield, M.P., and Birdsall, N.J.M.International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptorsPharmacol. Rev.50(2)279-290(1998) 3.Broadley, K.J., and Kelly, D.R.Muscarinic receptor agonists and antagonistsMolecules6(3)142-193(2001)