A6770 是一种具有口服活性的强效 1-磷酸鞘氨醇 (S1P) 裂解酶 (S1PL) 抑制剂。
货号:ajcx21570
CAS:1331754-16-5
分子式:C6H8N2O2
分子量：140.1
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.¹It induces accumulation of [³H]sphinganine-1-phosphate ([³H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC₅₀=<0.01 µM), an effect that is reduced in the presence of vitamin B₆(EC₅₀=<100 µM).

1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)