Afoxolaner 是一种具有口服活性的，对犬肩蜥的异恶唑啉杀虫剂/杀螨剂。Afoxolaner 作用于昆虫的 γ-氨基丁酸受体 (GABA) 和谷氨酸受体 (glutamate receptors)，抑制 GABA 和谷氨酸调节的氯离子 (chloride ions) 吸收，导致过度的神经元刺激和节肢动物死亡。
货号:ajcx16272
CAS:1093861-60-9
分子式:C26H17ClF9N3O3
分子量：625.87
溶解度:DMSO: ≥ 250 mg/mL (399.44 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

[1]. Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5. [2]. Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.