Mal-amido-PEG8-NHS ester 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
货号:ajcx36108
CAS:756525-93-6
分子式:C30H47N3O15
分子量：689.71
溶解度:DMSO : ≥ 100 mg/mL (144.99 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.