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EPQpYEEIPIYL
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EPQpYEEIPIYL图片
规格:98%
分子量:1473.52
包装与价格:
包装价格(元)
1mg询价
5mg询价

EPQpYEEIPIYL 是一种磷酸肽,是 Src 同源 2 (SH2) 结构域配体。 EPQpYEEIPIYL 通过与 SH2 域结合来激活 Src 家族成员 (例如 Lck,Hck,Fyn)。
货号:ajcx35588
CAS:147612-86-0
分子式:C66H97N12O24P
分子量:1473.52
溶解度:H2O : 2 mg/mL (1.36 mM; ultrasonic and adjust pH to 2 with HCl)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].

The hmT-derived phosphopeptide, pY324, which has the sequence EPQpYEEIPIYL, shows the highest affinity binding to GST fusion proteins of the Lck SH2 domain (5-fold higher than Lck’s affinity-for the Lck tail phosphopeptide) and the Src SH2 domain (44-fold higher than Src’s affinity for the Src tail phosphopeptide)[1].

[1]. G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1(2):99-105.
[2]. T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5(10):1313-23.

 
 
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