FAPI-46 是一种基于喹啉的靶向成纤维细胞活化蛋白 (FAP) 的放射性示踪剂。FAPI-46 具有更高的肿瘤吸收率和增长的肿瘤积累时间。FAPI-46 可用于多种不同癌症的肿瘤成像。
货号:ajcx34766
CAS:2374782-04-2
分子式:C41H57F2N11O9
分子量：885.96
溶解度:DMSO : 100 mg/mL (112.87 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers[1][2].

FAPI-46 (1-24 h) robustly binds to human FAP in human FAP-expressing HT-1080 cells[1].

FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging[1].

[1]. Loktev A, et, al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60(10):1421-1429.
[2]. Moon ES, et, al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA 5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19.