Thalidomide-NH-C4-NH-Boc

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	100mg
规格:	98%
市场价:	8643元
分子量:	444.48

Thalidomide-NH-C4-NH-Boc (compound 15) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。
货号:ajcx34286
CAS:2093388-52-2
分子式:C22H28N4O6
分子量：444.48
溶解度:DMSO : 100 mg/mL (224.98 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.