Honokiol DCA (Honokiol dichloroacetate) 是 Honokiol 的二氯乙酸酯类似物。Honokiol DCA 在体外可以抑制人前列腺癌细胞的生长并抑制雄激素受体 (AR) 蛋白水平。
货号:ajcx33348
CAS:1620160-42-0
分子式:C22H18Cl4O4
分子量：488.19
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level[1].

Honokiol DCA (20-40 μM; 24-48 h) inhibits the viability of LNCaP and C4-2 cells in a dose-and time-dependent manner[1].Honokiol DCA (5-20 μM; 10 days) inhibits clonogenicity of prostate cancer cells[1].Honokiol DCA (20-40 μM; 24-48 h) significantly decreases the level of androgen receptor (AR) and prostate specific antigen (PSA) protein in LNCaP cells[1].Honokiol DCA (40 μM; 24 h) significantly decreases AR promoter activity in LNCaP and C4-2 cells[1].

Honokiol类似物

[1]. Hahm ER, et, al. Honokiol inhibits androgen receptor activity in prostate cancer cells. Prostate. 2014 Apr;74(4):408-20.