Maytansine 是一种高效的微管靶向化合物，可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。
货号:ajcx33262
CAS:35846-53-8
分子式:C34H46ClN3O10
分子量：692.2
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[1].

Maytansine, at 6x10-8 M, irreversibly inhibits cell division in eggs of sea urchins and clams. Maytansine causes the disappearance of a mitotic apparatus or prevents one from forming if added at early stages. Maytansine inhibits in vitro polymerization of tubulin[2].

[1]. Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010;9(10):2689-2699.
[2]. Remillard S, et al. Antimitotic activity of the potent tumor inhibitor maytansine. Science. 1975;189(4207):1002-1005.