EBOV/MARV-IN-1是一种有效的埃博拉病毒(EBOV)和马尔堡病毒(MARV)抑制剂，在HeLa细胞中具有广谱活性(EC50=0.31和0.82µM)和低细胞毒性(SI>100)。
货号:ajcx30572
CAS:2479465-67-1
分子式:C25H30F3N3O2
分子量：461.52
溶解度:DMSO: 100 mg/mL (216.68 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells[1].

EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088)[1].

[1]. Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225.