C27H34ClFN2O4.HCl
货号:ajcx28108
CAS:N/A
分子式:C27H34ClFN2O4.HCl
分子量：541.48
溶解度:DMSO|54.15|100|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1β and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo. Brain penetrant. Cell-permeable.