T 3364366 是一种可逆的、缓慢结合的噻吩并嘧啶酮 delta-5 去饱和酶 (D5D) 抑制剂，在 HepG2 和 RLN-10 细胞中的 IC50 分别为 1.9 nM 和 2.1 nM。
货号:ajcx27380
CAS:1356354-09-0
分子式:C18H16F3N3O3S2
分子量：443.46
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and reversible fatty acid desaturase 1 (FADS1; Δ5 desaturase) inhibitor (IC50 values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6 desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.

Miyahisa et al (2016) T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 7 868 PMID:27660693