BX 430 是一种有效的选择性非竞争性变构人 P2X4 受体通道拮抗剂，IC50 为 0.54 μM。
货号:ajcx27112
CAS:688309-70-8
分子式:C15H15Br2N3O
分子量：413.11
溶解度:DMSO: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

Ase et al (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 87 606 PMID:25597706