罗沙替丁是醋酸罗沙替丁盐酸盐的活性代谢物，是组胺 H2 受体拮抗剂。
货号:ajcx26074
CAS:78273-80-0
分子式:C17H26N2O3
分子量：306.4
溶解度:DMSO: up to 25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Roxatidine is a histamine H₂receptor antagonist and major active metabolite of roxatidine acetate .¹Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC₅₀= 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA₂= 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin .²

1.Sewing, K.-F., Beil, W., and Hannemann, H.Comparative pharmacology of histamine H2-receptor antagonistsDrugs35(Suppl. 3)25-29(1988) 2.Umegaki, E., Yoda, Y., Tokioka, S., et al.Protective effect of roxatidine against indomethacin induced small intestinal mucosal injury in ratsJ. Gastroenterol. Hepatol.25(Suppl. 1)S35-S40(2010)