An internal standard for the quantification of prostaglandin E1
货号:ajcx23334
CAS:211105-33-8
分子式:C20H30D4O5
分子量：358.5
溶解度:DMF: >100 mg/ml (from PGE1),DMSO: >50 mg/ml (from PGE1),Ethanol: >50 mg/ml (from PGE1),PBS pH 7.2: >1.6 mg/ml (from PGE1)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prostaglandin E₁-d₄(PGE₁-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGE₁by GC-or LC-mass spectrometry. PGE₁is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.¹Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC₅₀of PGE₁for the inhibition of ADP-induced human platelet aggregation is 40 nM.^2,3The vasorelaxant and anti-hypertensive effects of PGE₁are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.^4,5In human males, the intracavernosal effective dose range for PGE₁is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.⁴

1.Cawello, W., Schweer, H., Dietrich, B., et al.Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunctionJournal of Urology1581403-1407(1997) 2.Kobzar, G., Mardla, V., JÄrving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991) 3.Okada, F., Nukada, T., Yamauchi, Y., et al.The hypotensive effect of prostaglandin E1 on hypertensive cases of various typesProstaglandins799-106(1974) 4.Padma-Nathan, H., Hellstrom, W.J.G., Kaiser, F.E., et al.Treatment of men with erectile dysfunction with transurethral alprostadilNew England Journal of Medicine3361-7(1997) 5.Olley, P.M., and Coceani, F.Prostaglandins and the ductus arteriosusAnnual Reviews of Medicine32375-3785(1981)