A neuropeptide with diverse biological activities
货号:ajcx23204
CAS:N/A
分子式:C28H54D4NO7P
分子量：555.7
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 20 mg/ml,Water: 20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PAF C-18-d₄contains four deuterium atoms at the 9, 9', 10, and 10' positions. It is intended for use as an internal standard for the quantification of PAF C-18 by GC-or LC-mass spectrometry. PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.¹It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages.²PAF C-18 induces the release of PGE₂and TXB₂from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages.³Pathological processes involving PAF include necrotizing enterocolitis,⁴inflammation, asthma, and allergy.⁵

1.Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorThe Journal of Biological Chemisty26517381-17384(1990) 2.Stewart, A.G., and Grigoriadis, G.Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophagesJournal of Lipid Mediators4299-308(1991) 3.Hartung, H.P.Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2 production, spreading, and the influence of calmodulin-inhibitor W-7FEBS Letters160209-212(1983) 4.Wang, H., Tan, X.D., Qu, X.W., et al.Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximidePediatric Research42597-603(1997) 5.Sturk, A., Wouter Ten Cate, J., Hosford, D., et al.The synthesis, catabolism, and pathophysiological role of platelet-activating factorAdvances in Lipid Research23219-276(1989)