An internal standard for the quantification of imatinib
货号:ajcx22652
CAS:1134803-18-1
分子式:C29H28D3N7O
分子量：496.6
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Imatinib-d₃is intended for use as an internal standard for the quantification of imatinib by GC- or LC-MS. Imatinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit.¹It inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC₅₀s = ~0.3 and ~0.1 μM, respectively).^1,2Imatinib inhibits the proliferation of Bcr-Abl-dependent R10(-) cells (IC₅₀s = ~35-40 nM) and HMC-1 cells expressing constitutively active c-Kit in a concentration-dependent manner.^1,3It prolongs survival in a mouse model of chronic myeloid leukemia when administered at a dose of 100 mg/kg twice per day.⁴Imatinib (25 and 50 µM) also inhibits the replication of Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in Vero E6 cells.⁵It reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, when used at a concentration of 10 µMviainhibition of IBV surface glycoprotein protein-induced syncytia formation and virus-cell fusion.⁶Formulations containing imatinib have been used in the treatment of various cancers.

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