A neuropeptide with diverse biological activities
货号:ajcx22418
CAS:N/A
分子式:C20H25D9O5
分子量：363.5
溶解度:DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ent-8-iso-15(S)-Prostaglandin F_2α-d₉(ent-8(S)-15-epi-PGF_2α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of ent-8-iso-15(S)-PGF_2αby GC-or LC-mass spectrometry. Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-PGF_2αis a potent vasoconstrictor of porcine retinal and brain microvessels with EC₅₀values of 15 and 24 nM, respectively.¹This isoprostane is about ten-fold more potent than 8-iso-PGF_2αin a whole blood platelet aggregation inhibition assay.²

1.Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al.Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculatureFree Radical Biology & Medicine36(2)163-172(2004) 2.Shizuka, M., and Snapper, M.L.Selective synthesis of ent-15-epi-F2t-isoprostane and a deuterated derivativeSynthesis152397-2403(2007)