An internal standard for the quantification of 4β-hydroxy cholesterol
货号:ajcx21448
CAS:1246302-80-6
分子式:C27H39D7O2
分子量：409.7
溶解度:Chloroform: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4β-hydroxy Cholesterol-d₇is intended for use as an internal standard for the quantification of 4β-hydroxy cholesterol by GC- or LC-MS. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.¹It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.¹4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.

1.Dicfalusy, U., Kanebratt, K.P., Bredberg, E., et al.4β-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicinBr. J. Clin. Pharmacol.67(1)38-43(2009)