An internal standard for the quantification of (S)-pramipexole
货号:ajcx20966
CAS:1217601-58-5
分子式:C10H12D5N3S.2HCl
分子量：289.3
溶解度:Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(S)-Pramipexole-d₅is intended for use as an internal standard for the quantification of (S)-pramipexole by GC- or LC-MS. (S)-Pramipexole is a dopamine D_2S, D_2L, D₃, and D₄receptor agonist (EC₅₀s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [³⁵S]GTPγS binding assay).¹It is also a partial agonist of α_2A-adrenergic receptors (α_2A-ARs; EC₅₀= 3,548.13 nM). (S)-Pramipexole is selective for dopamine D_2-4receptors (K_is = 954.99, 1,698.24, 12.59, 128.82 nM for D_2S, D_2L, D₃, and D₄receptors, respectively, in a radioligand binding assay) over D₁and D₅receptors (K_is = >10,000 nM for both).²It prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets when administered at a dose of 60 μg/kg per day before, during, and after administration of MPTP.³Formulations containing (S)-pramipexole have been used in the treatment of Parkinson's disease and restless legs syndrome.

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