The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids.
货号:ajcx17902
CAS:N/A
分子式:C25H46O21P4S•4Na
分子量：930.5
溶解度:Water: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. 3-PT-PtdIns(3,4,5)-P3 is an analog of PtdIns-(3,4,5)-P3 that is resistant to hydrolysis by PTEN. It has a 5-fold reduced affinity for the specific PtdIns(3,4,5)-P3-binding protein GRP1 and increases sodium transport in A6 cell monolayers.