PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种基于 PROTAC 的 SKG3 降解剂。PROTAC SGK3 degrader-1 (0.3 μM) 在 2 小时内诱导 50％ 内源性 SGK3 降解，8 小时观察到 80％SGK3 的降解，并伴随着 NDRG1 (SGK3 底物) 的磷酸化损失 [1] 。
货号:ajcx16610
CAS:2381320-35-8
分子式:C57H73FN10O11S2
分子量：1157.38
溶解度:DMSO: ≥ 100 mg/mL (86.40 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1( an SGK3 substrate)[1].

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.