Urolithin B 是 ellagitannins 的肠道微生物代谢产物之一，具有抗炎和抗氧化作用。Urolithin B 通过降低 IκBα 的磷酸化和降解来抑制NF-κB活性。Urolithin B 抑制 JNK、ERK 和 Akt 的磷酸化，增强 AMPK 的磷酸化。Urolithin B 也是骨骼肌质量的调节因子。
货号:ajcx15160
CAS:1139-83-9
分子式:C13H8O3
分子量：212.2
溶解度:DMSO: 250 mg/mL (1178.13 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass[1][2].

[1]. Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57. [2]. Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597.