NP-12 (TFA) 是 PD-1 信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。NP-12 (TFA) 具有免疫激活作用、良好的抗肿瘤活性，具有治疗免疫相关不良事件 (irAEs) 的潜力。
货号:ajcx14038
CAS:N/A
分子式:C144H227F3N40O50
分子量：3375.63
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NP-12 (TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. NP-12 (TFA) exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs)[1]. PD-1 signaling pathway[1]

[1]. Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18(6):1081-1091.