RO-7是甲型和乙型流感病毒的二代聚合酶PA亚基内切核酸酶抑制剂。
货号:ajcx12768
CAS:1370241-45-4
分子式:C24H20F3N3O3S
分子量：487.49
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].

RO-7 protects mice from lethal challenge with both influenza A and B viruses[1].

[1]. Jones JC, et al. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation InfluenzaVirus Endonuclease Inhibitors. MBio. 2018 Apr 24;9(2). pii: e00430-18.