CCR2antagonist1是C-C趋化因子受体2型(CCR2)高亲和力、长时间作用的拮抗剂，其Ki值为2.4nM。
货号:ajcx12412
CAS:1683534-96-4
分子式:C28H32BrF3N2O
分子量：549.47
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].

[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.