CDK4/6-IN-6 (example A94) 是一种有效的 CDK4/CDK6 抑制剂，对CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 值为 0.6 nM 和 13.9 nM。
货号:ajcx38324
CAS:2380321-51-5
分子式:C22H27ClFN5O3
分子量：463.93
溶解度:DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].

CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.