Abemaciclib metabolite M18 (LSN3106729) hydrochloride，Abemaciclib 的代谢物，是一种具有抗肿瘤活性的 CDK 抑制剂。Abemaciclib metabolite M18 hydrochloride 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。
货号:ajcx36246
CAS:N/A
分子式:C25H29ClF2N8O
分子量：531
溶解度:DMSO : 125 mg/mL (235.40 mM; Need ultrasonic)|H2O : 100 mg/mL (188.32 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].

[1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study.
[2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.