(E/Z)-Sivopixant (Compound I-127) 是一种有效的 P2X3 受体拮抗剂，IC50 为 4 nM。(E/Z)-Sivopixant 可用于呼吸系统疾病研究。
货号:ajcx33964
CAS:1640808-39-4
分子式:C25H22ClN5O5
分子量：507.93
溶解度:DMSO : 100 mg/mL (196.88 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research[1].

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors It has been suggested that it is involved in information transmission in the respiratory organs[1].

[1]. Kai, Hiroyuki, et al. Amino-triazine derivatives and pharmaceutical composition containing said derivatives. WO2014200078A1.