NH2-PEG5-OH是一种PROTAClinker，属于PEG类。NH2-PEG5-OH可用于合成PROTAC分子。NH2-PEG5-OH也是一种不可降解(non-cleavable)的含5个单元PEG的ADClinker，可用于合成抗体偶联药物(ADC)。
货号:ajcx31716
CAS:34188-11-9
分子式:C10H23NO5
分子量：237.29
溶解度:DMSO: 100 mg/mL (421.43 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.