Propargyl-PEG2-amine是一种不可降解(non-cleavable)的ADClinker，用于抗体偶联药物(ADCs)的合成。Propargyl-PEG2-amine是一种PROTAClinker，属于PEG类。Propargyl-PEG2-NH2可用于合成一系列PROTAC分子。
货号:ajcx31340
CAS:944561-44-8
分子式:C7H13NO2
分子量：143.18
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A. [2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.