Boc-NH-PEG2-CH2CH2COOH是一种基于PEG的PROTAClinker，用于合成PROTAC。
货号:ajcx30294
CAS:1365655-91-9
分子式:C12H23NO6
分子量：277.31
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.