BRD 6989 是天然产物皮质抑素 A (dCA) 的类似物，可抑制 CDK8 并上调 IL-10。
货号:ajcx27590
CAS:642008-81-9
分子式:C16H16N4
分子量：264.33
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID:28805801